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- Novel gene or DNA fragment mapping on banded chromosomes (human, mouse, and rat)
- Cross species mapping utilizing alternate species cDNA probes. This can be done, for example, by mapping a human locus using mouse, rat, other mammalian and even fly cDNA.
- Evaluate syntenic relationships between human, mouse, rat and other species
- Confirm EST information
- Confirm mapping data generated from a radiation hybrids panel
- Deletion/amplification studies of a novel gene in tumor cell lines
Figure 1: Gene Mapping on Human Chromosomes
FISH detection on DAPI banded human chromosomes. FISH mapping on
banded chromosomes is effective for chromosome
identification and for the precise mapping. Since
condensation along a chromosome is not consistent throughout the various stages of
metaphase, it is not accurate to map genes by measuring the position
on non-banded chromosomes (such as when co-hybridization with known
probes is used to identify the chromosomes).
- Simonet WS, Lacey DL, Dunstan CR, et al.
Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
CELL 89: (2) 309-319 APR 18 1997
- Cecconi F, Alvarez-Bolado G, Meyer BI, et al.
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
CELL 94: (6) 727-737 SEP 18 1998
- Zheng LL, Sekerkova G, Vranich K, et al.
The def jerker mouse has a mutation in the gene encoding the espin actin -bundling proteins of hair cell sterocilia and lacks espins
CELL 102 (3): 377-385 AUG 4 2000
- GarciaAnoveros J, Derfler B, NevilleGolden J, et al.
BNaC1 and BNaC2 constitute at new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
P NATL ACAD SCI USA 94: (4) 1459-1464 FEB 18 1997
- Boisclair YR, Seto D, Hsieh S, et al.
Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex
P NATL ACAD SCI USA 93: (19) 10028-10033 SEP 17 1996
- Cimprich KA, Shin TB, Keith CT, et al.
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
P NATL ACAD SCI USA 93: (7) 2850-2855 APR 2 1996
For more references, please check out the publications in the reliability section.
